Publikationen der ALS-Forschungsgruppe an der Charité

  • Symptomatic pharmacotherapy in ALS: data analysis from a platform-based medication management programme.

    Meyer T, Kettemann D, Maier A, Grehl T, Weyen U, Grosskreutz J, Steinbach R, Norden J, George A,Hermann A, Guenther R, Petri S, Schreiber-Katz O, Dorst J, Ludolph AC, Walter B, Münch C, Spittel S.
    J Neurol Neurosurg Psychiatry. 2020 Apr 21. pii: jnnp-2020-322938. doi: 10.1136/jnnp-2020-322938. [Epub ahead of print]
    PMID: 32317400

    J Neurol Neurosurg Psychiatry, April 2020

    Real world experience of patients with amyotrophic lateral sclerosis (ALS) in the treatment of spastic using tetrahydrocannabinol:cannabidiol (THC:CBD).

    Meyer T, Funke A, Münch C, Kettemann D, Maier A, Walter B, Thomas A, Spittel S.
    BMC Neurol. 2019 Sep 7;19(1):222. doi: 10.1186/s12883-019-1443-y.
    PMID: 31493784

    BMC Neurology, September 2019

    Patient-Reported Outcome of Physical Therapy in Amyotrophic Lateral Sclerosis: Observational Online Study

    Meyer R, Spittel S, Steinfurth L, Funke A, Kettemann D, Münch C, Meyer T, Maier A.
    JMIR Rehabil Assist Technol. 2018 Nov 12;5(2):e10099. doi: 10.2196/10099.
    P    MID: 30425026

    JMIR Publications, Januar 2019

    Provision of assistive technology devices among peolple with ALS in Germany: a platform-case management approach.

    Funke A, Spittel S, Grehl T, Grosskreutz J, Kettemann D, Petri S, Weyen U, Weydt P, Dorst J, Ludolph AC, Baum P, Oberstadt M, Jordan B, Hermann A, Wolf J, Boentert M, Walter B, Gajewski N, Maier A, Münch C,Meyer T.
    Amyotroph Lateral Scler Frontotemporal Degener. 2018 Aug;19(5-6):342-350. doi: 10.1080/21678421.2018.1431786. Epub 2018 Jan 30.
    P    MID: 29382225

    Journal Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, August 2018

    Clinical characteristics and course of dying in patients with amyotrophic lateral sclerosis withdrawing from long-term ventilation.

    Kettemann D, Funke A, Maier A, Rosseau S, Meyer R, Spittel S, Münch C, Meyer T.
    Amyotroph Lateral Scler Frontotemporal Degener. 2017 Feb;18(1-2):53-59. doi: 10.1080/21678421.2016.1214734. Epub 2016 Aug 18.
    P    MID: 27534566

    Journal Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Februar 2017

    Interleukin-1 Antagonist Anakinra in Amyotriphic Lateral Sclerosis – A Pilot Study.

    Maier A, Deigendesch N, Müller K, Weishaupt JH, Krannich A, Röhle R, Meissner F, Molawi K, Münch C, Holm T, Meyer R, Meyer T, Zychlinsky A.
    PLoS One. 2015 Oct 7;10(10):e0139684. doi: 10.1371/journal.pone.0139684. eCollection 2015.
    P    MID: 26444282

    Plos One, Oktober 2015

    Provision of assistive devices in amyotrophic lateral sclerosis. Analysis of 3 years case management in an internet-based supply network.

    Funke A, Grehl T, Großkreutz J, Münch C, Walter B, Kettemann D, Karnapp C, Gajewski N, Meyer R, Maier A, Gruhn KM, Prell T, Kollewe K, Abdulla S, Kobeleva X, Körner S, Petri S, Meyer T.
    Nervenarzt. 2015 Aug;86(8):1007-17. doi: 10.1007/s00115-015-4398-2.
    P    MID: 26220007

    Nervenarzt, August 2015

    Svere loss of appetite in amyotrophic lateral sclerosis patients: online self-assessment study.

    Holm T, Maier A, Wicks P, Lang D, Linke P, Münch C, Steinfurth L, Meyer R, Meyer T.
    Interact J Med Res. 2013 Apr 17;2(1):e8. doi: 10.2196/ijmr.2463.
    P    MID: 23608722

    JMIR Publications, April 2013

    Concomitant amyotrophic lateral sclerosis and paraclinical laboratory features of multiple sclerosis: coincidence or causal relationship?

    Borisow N, Meyer T, Paul F.
    BMJ Case Rep. 2013 Jan 23;2013:bcr2012007975. doi: 10.1136/bcr-2012-007975.
    P    MID: 23349176

    BMJ Case Reports, Januar 2013

    Online assessment of ALS functional rating scale compares well to in-clinic evaluation: a prospective trial.

    Maier A, Holm T, Wicks P, Steinfurth L, Linke P, Münch C, Meyer R, Meyer T.
    Amyotroph Lateral Scler. 2012 Feb;13(2):210-6. doi: 10.3109/17482968.2011.633268.
    P    MID: 22292842

    BMJ Case Reports, Januar 2013

    Motor neuron diseases.

    Petri S, Meyer T.
    Nervenarzt. 2011 Jun;82(6):697-706. doi: 10.1007/s00115-010-2967-y.
    PMID: 21626001

    Der Nervenarzt, Juni 2011

    Heterozygous S44L missense change of the spastin gene in amyotrophic lateral sclerosis.

    Münch C, Rolfs A, Meyer T.
    Amyotroph Lateral Scler. 2008 Aug;9(4):251-3. doi: 10.1080/17482960801900172.
    P    MID: 18608088

    Amyotrophic Lateral Sclerosis, August 2008

    Elective termination of respiratory therapy in amyotrophic lateral sclerosis.

    Meyer T, Dullinger JS, Münch C, Keil JP, Hempel E, Rosseau S, Borisow N, Linke P.
    Nervenarzt. 2008 Jun;79(6):684-90. doi: 10.1007/s00115-008-2439-9.
    P    MID: 18330539

    Nervenarzt, Juni 2008

    Thalidomide causes sinus bradycardia in ALS.

    Meyer T, Maier A, Borisow N, Dullinger JS, Splettstösser G, Ohlraun S, Münch C, Linke P.
    J Neurol. 2008 Apr;255(4):587-91. doi: 10.1007/s00415-008-0756-3. Epub 2008 Apr 21.
    P    MID: 18425621

    Journal of Neurology, April 2008

    Progressive muscle atrophy. A rarely diagnosed variant of amyotrophic lateral sclerosis.

    Meyer T, Münch C, van Landeghem FK, Borisow N, Dullinger J, Linke P.
    Nervenarzt. 2007 Dec;78(12):1383-8. doi: 10.1007/s00115-007-2288-y.
    P    MID: 17516042

    Nervenarzt, Dezember 2007

    Heterozygous R1101K mutation of the DCTN1 gene in a family with ALS and FTD.

    Münch C, Rosenbohm A, Sperfeld AD, Uttner I, Reske S, Krause BJ, Sedlmeier R, Meyer T, Hanemann CO, Stumm G, Ludolph AC.
    Ann Neurol. 2005 Nov;58(5):777-80. doi: 10.1002/ana.20631.
    P    MID: 16240349

    Annals of Neurology, November 2005

    Frequency of a tau genotype in amyotrophic lateral sclerosis.

    Münch C, Prechter F, Xu R, Linke P, Prudlo J, Kuzma M, Kwiecinski H, Ludolph AC, Meyer T.
    J Neurol Sci. 2005 Sep 15;236(1-2):13-6. doi: 10.1016/j.jns.2005.04.004.
    P    MID: 16005901

    Journal of the Neurological Sciences, September 2005

    Early-onset ALS with long-term survival associated with spastin gene mutation.

    Meyer T, Schwan A, Dullinger JS, Brocke J, Hoffmann KT, Nolte CH, Hopt A, Kopp U, Andersen P, Epplen JT, Linke P.
    Neurology. 2005 Jul 12;65(1):141-3. doi: 10.1212/01.wnl.0000167130.31618.0a.
    P    MID: 16009903

    Neurology, July 2005

    Point mutations of the p150 subunit of dynactin (DCTN1) gene in ALS.

    Münch C, Sedlmeier R, Meyer T, Homberg V, Sperfeld AD, Kurt A, Prudlo J, Peraus G, Hanemann CO, Stumm G, Ludolph AC.
    Neurology. 2004 Aug 24;63(4):724-6. doi: 10.1212/01.wnl.0000134608.83927.b1.
    P    MID: 15326253

    Neurology, August 2004

    Chromosomal translocation t(18;21)(q23;q22.1) indicates novel susceptibility loci for frontotemporal dementia with ALS.

    Prudlo J, Alber B, Kalscheuer VM, Roemer K, Martin T, Dullinger J, Sittinger H, Niemann S, Heutink P, Ludolph AC, Ropers HH, Zang K, Meyer T.
    Ann Neurol. 2004 Jan;55(1):134-8. doi: 10.1002/ana.10822.
    PMID: 14705124

    Annals of Neurology, Januar 2004

    High rate of constitutional chromosomal rearrangements in apparently sporadic ALS.

    Meyer T, Alber B, Roemer K, Martin T, Kalscheuer VM, Göttert E, Zang KD, Ludolph AC, Ropers HH, Prudlo J.
    Neurology. 2003 Apr 22;60(8):1348-50. doi: 10.1212/01.wnl.0000055088.52681.f1.
    P    MID: 12707441

    Neurology, April 2003

    The RNA of the glutamate transporter EAAT2 is variably spliced in amyotrophic lateral sclerosis and normal individuals.

    Meyer T, Fromm A, Münch C, Schwalenstöcker B, Fray AE, Ince PG, Stamm S, Grön G, Ludolph AC, Shaw PJ.
    J Neurol Sci. 1999 Nov 15;170(1):45-50. doi: 10.1016/s0022-510x(99)00196-3.
    P    MID: 10540035

    Journal of the Neurological Sciences, November 1999

    The EAAT2 (GLT-1) gene in motor neuron disease: absence of mutations in amyotrophic lateral sclerosis and a point mutation in patients with hereditary spastic paraplegia?

    Meyer T, Münch C, Völkel H, Booms P, Ludolph AC.
    J Neurol Neurosurg Psychiatry. 1998 Oct;65(4):594-6. doi: 10.1136/jnnp.65.4.594.
    PMID: 9771796

    Journal of Neurology, Neurosurgery and Psychiatry, Oktober 1998

    Studies of the coding region of the neuronal glutamate transporter gene in amyotrophic lateral sclerosis.

    Meyer T, Lenk U, Küther G, Weindl A, Speer A, Ludolph AC.
    Ann Neurol. 1995 Jun;37(6):817-9. doi: 10.1002/ana.410370618.
    P    MID: 7778858

    Annals of Neurology, Juni 1995

     

Publikationen mit Beteiligung der ALS-Forschungsgruppe an der Charité

  • Effect of High-Caloric Nutrition on Survival in Amyotrophic Lateral Sclerosis.

    Ludolph AC, Dorst J, Dreyhaupt J, Weishaupt JH, Kassubek J, Weiland U, Meyer T, Petri S, Hermann A, Emmer A, Grosskreutz J, Grehl T, Zeller D, Boentert M, Schrank B, Prudlo J, Winkler AS, Gorbulev S, Roselli F, Schuster J, Dupuis L; LIPCAL-ALS Study Group.Ann Neurol. 2020 Feb;87(2):206-216. doi: 10.1002/ana.25661. [Epub ahead of print]
    PMID    : 31849093

    Annals of Neurology, Februar 2020

    Prognostic factors in ALS: a comparison between Germany and China.

    Dorst J, Chen L, Rosenbohm A, Dreyhaupt J, Hübers A, Schuster J, Weishaupt JH, Kassubek J, Gess B, Meyer T, Weyen U, Hermann A, Winkler J, Grehl T, Hagenacker T, Lingor P, Koch JC, Sperfeld A, Petri S, Großkreutz J, Metelmann M, Wolf J, Winkler AS, Klopstock T, Boentert M, Johannesen S, Storch A, Schrank B, Zeller D, Liu XL, Tang L, Fan DS, Ludolph AC.
    J Neurol. 2019 Jun;266(6):1516-1525. doi: 10.1007/s00415-019-09290-4. Epub 2019 Mar 28
    PMID: 30923935

    Journal of Neurology, Juni 2019

    GABAB receptor encephalitis in a patient diagnosed with amyotrophic lateral sclerosis.

    Schumacher H, Meyer T, Prüss H.
    BMC Neurol. 2019 Mar 14;19(1):41. doi: 10.1186/s12883-019-1269-7.
    PMID: 30871492

    BMC Neurology, März 2019

    Safety and efficacy of rasagiline as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomised, double-blind, parallel-group, placebo-controlled, phase 2 trial

    Ludolph AC, Schuster J, Dorst J, Dupuis L, Dreyhaupt J, Weishaupt JH, Kassubek J, Weiland U, Petri S, Meyer T, Grosskreutz J, Schrank B, Boentert M, Emmer A, Hermann A, Zeller D, Prudlo J, Winkler AS, Grehl T, Heneka MT, Wollebæk Johannesen S, Göricke B; RAS-ALS Study Group.
    Lancet Neurol. 2018 Aug;17(8):681-688. doi: 10.1016/S1474-4422(18)30176-5. Epub 2018 Jun 19.
    PMID: 29934198

    The Lancet Neurology, August 2018

    Comprehensive analysis of the mutation spectrum in 301 German ALS families.

    Müller K, Brenner D, Weydt P, Meyer T, Grehl T, Petri S, Grosskreutz J, Schuster J, Volk AE, Borck G, Kubisch C, Klopstock T, Zeller D, Jablonka S, Sendtner M, Klebe S, Knehr A, Günther K, Weis J, Claeys KG, Schrank B, Sperfeld AD, Hübers A, Otto M, Dorst J, Meitinger T, Strom TM, Andersen PM, Ludolph AC, Weishaupt JH; German ALS network MND-NET.
    J Neurol Neurosurg Psychiatry. 2018 Aug;89(8):817-827. doi: 10.1136/jnnp-2017-317611. Epub 2018 Apr 12.
    PMID: 29650794

    Journal of Neurology, August 2018

    Therapeutic decision in ALS patients: cross-cultural differences and clinical implications.

    Andersen PM, Kuzma-Kozakiewicz M, Keller J, Aho-Oezhan HEA, Ciecwierska K, Szejko N, Vázquez C, Böhm S, Badura-Lotter G, Meyer T, Petri S, Linse K, Hermann A, Semb O, Stenberg E, Nackberg S, Dorst J, Uttner I, Häggström AC, Ludolph AC, Lulé D.
    J Neurol. 2018 Jul;265(7):1600-1606. doi: 10.1007/s00415-018-8861-4. Epub 2018 May 4.
    PMID: 29728768

    Journal of Neurology, Juli 2018

    The metabolic and endocrine characteristics in spinal and bulbar muscular atrophy.

    Rosenbohm A, Hirsch S, Volk AE, Grehl T, Grosskreutz J, Hanisch F, Herrmann A, Kollewe K, Kress W, Meyer T, Petri S, Prudlo J, Wessig C, Müller HP, Dreyhaupt J, Weishaupt J, Kubisch C, Kassubek J, Weydt P, Ludolph AC.
    J Neurol. 2018 May;265(5):1026-1036. doi: 10.1007/s00415-018-8790-2. Epub 2018 Feb 20.
    PMID: 29464380

    Journal of Neurology, Mai 2018

    Hot-spot KIF5 Amutations cause familial ALS.

    Brenner D, Yilmaz R, Müller K, Grehl T, Petri S, Meyer T, Grosskreutz J, Weydt P, Ruf W, Neuwirth C, Weber M, Pinto S, Claeys KG, Schrank B, Jordan B, Knehr A, Günther K, Hübers A, Zeller D, Kubisch C, Jablonka S, Sendtner M, Klopstock T, de Carvalho M, Sperfeld A, Borck G, Volk AE, Dorst J, Weis J, Otto M, Schuster J, Del Tredici K, Braak H, Danzer KM, Freischmidt A, Meitinger T, Strom TM, Ludolph AC, Andersen PM, Weishaupt JH; German ALS network MND-NET.
    Brain. 2018 Mar 1;141(3):688-697. doi: 10.1093/brain/awx370.
    PMID: 29342275

    Brain, März 2018

    July 2017 ENCALS statement on edaravone.

    Al-Chalabi A, Andersen PM, Chandran S, Chio A, Corcia P, Couratier P, Danielsson O, de Carvalho M, Desnuelle C, Grehl T, Grosskreutz J, Holmøy T, Ingre C, Karlsborg M, Kleveland G, Koch JC, Koritnik B, KuzmaKozakiewicz M, Laaksovirta H, Ludolph A, McDermott C, Meyer T, Mitre Ropero B, Mora Pardina J, Nygren I, Petri S, Povedano Panades M, Salachas F, Shaw P, Silani V, Staaf G, Svenstrup K, Talbot K, Tysnes OB, Van Damme P, van der Kooi A, Weber M, Weydt P, Wolf J, Hardiman O, van den Berg LH.
    Amyotroph Lateral Scler Frontotemporal Degener. 2017 Nov;18(7-8):471-474. doi: 10.1080/21678421.2017.1369125. Epub 2017 Oct 4.
    PMID: 28975816

    Amyotroph Lateral Scler Frontotemporal Degener , November 2017

    Sequence variations in C9orf72 downstream of the hexanucleotide repeat region and its effect on repeat-primed PCR interpretation: a large multinational screening study.

    Nordin A, Akimoto C, Wuolikainen A, Alstermark H, Forsberg K, Baumann P, Pinto S, de Carvalho M, Hübers A, Nordin F, Ludolph AC, Weishaupt JH, Meyer T, Grehl T, Schweikert K, Weber M, Burkhardt C, Neuwirth C, Holmøy T, Morita M, Tysnes OB, Benatar M, Wuu J, Lange DJ, Bisgård C, Asgari N, Tarvainen I, Brännström T, Andersen PM
    Amyotroph Lateral Scler Frontotemporal Degener. 2017 May;18(3-4):256-264. doi: 10.1080/21678421.2016.1262423. Epub 2016 Dec 12.
    PMID: 27936955

    Amyotroph Lateral Scler Frontotemporal Degener , Mai 2017

    Diagnostic and prognostic significance of neurofilament ligth chain NF-L, but not progranulin and S100B, in the course of amyotrophic lateral sclerosis: Data from the German MND-net.

    Steinacker P, Huss A, Mayer B, Grehl T, Grosskreutz J, Borck G, Kuhle J, Lulé D, Meyer T, Oeckl P, Petri S, Weishaupt J, Ludolph AC, Otto M.
    Amyotroph Lateral Scler Frontotemporal Degener. 2017 Feb;18(1-2):112-119. doi: 10.1080/21678421.2016.1241279. Epub 2016 Nov 5.
    PMID: 27819158

    Amyotroph Lateral Scler Frontotemporal Degener , Februar 2017

    Genome-wide association analysis identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.

    van Rheenen W, Shatunov A, Dekker AM, McLaughlin RL, Diekstra FP, Pulit SL, van der Spek RA, Võsa U, de Jong S, Robinson MR, Yang J, Fogh I, van Doormaal PT, Tazelaar GH, Koppers M, Blokhuis AM, Sproviero W, Jones AR, Kenna KP, van Eijk KR, Harschnitz O, Schellevis RD, Brands WJ, Medic J, Menelaou A, Vajda A, Ticozzi N, Lin K, Rogelj B, Vrabec K, Ravnik-Glavač M, Koritnik B, Zidar J, Leonardis L, Grošelj LD, Millecamps S, Salachas F, Meininger V, de Carvalho M, Pinto S, Mora JS, Rojas-García R, Polak M, Chandran S, Colville S, Swingler R, Morrison KE, Shaw PJ, Hardy J, Orrell RW, Pittman A, Sidle K, Fratta P, Malaspina A, Topp S, Petri S, Abdulla S, Drepper C, Sendtner M, Meyer T, Ophoff RA, Staats KA, Wiedau-Pazos M, Lomen-Hoerth C, Van Deerlin VM, Trojanowski JQ, Elman L, McCluskey L, Basak AN, Tunca C, Hamzeiy H, Parman Y, Meitinger T, Lichtner P, Radivojkov-Blagojevic M, Andres CR, Maurel C, Bensimon G, Landwehrmeyer B, Brice A, Payan CA, Saker-Delye S, Dürr A, Wood NW, Tittmann L, Lieb W, Franke A, Rietschel M, Cichon S, Nöthen MM, Amouyel P, Tzourio C, Dartigues JF, Uitterlinden AG, Rivadeneira F, Estrada K, Hofman A, Curtis C, Blauw HM, van der Kooi AJ, de Visser M, Goris A, Weber M, Shaw CE, Smith BN, Pansarasa O, Cereda C, Del Bo R, Comi GP, D’Alfonso S, Bertolin C, Sorarù G, Mazzini L, Pensato V, Gellera C, Tiloca C, Ratti A, Calvo A, Moglia C, Brunetti M, Arcuti S, Capozzo R, Zecca C, Lunetta C, Penco S, Riva N, Padovani A, Filosto M, Muller B, Stuit RJ; PARALS Registry; SLALOM Group; SLAP Registry; FALS Sequencing Consortium; SLAGEN Consortium; NNIPPS Study Group, Blair I, Zhang K, McCann EP, Fifita JA, Nicholson GA, Rowe DB, Pamphlett R, Kiernan MC, Grosskreutz J, Witte OW, Ringer T, Prell T, Stubendorff B, Kurth I, Hübner CA, Leigh PN, Casale F, Chio A, Beghi E, Pupillo E, Tortelli R, Logroscino G, Powell J, Ludolph AC, Weishaupt JH, Robberecht W, Van Damme P, Franke L, Pers TH, Brown RH, Glass JD, Landers JE, Hardiman O, Andersen PM, Corcia P, Vourc’h P, Silani V, Wray NR, Visscher PM, de Bakker PI, van Es MA, Pasterkamp RJ, Lewis CM, Breen G, Al-Chalabi A, van den Berg LH, Veldink JH.
    Nat Genet. 2016 Sep;48(9):1043-8. doi: 10.1038/ng.3622. Epub 2016 Jul 25.
    PMID: 27455348

    Nature Genetics , September 2016

    A mapping review of international guidance on the management and care of amyotrophic lateral sclerosis (ALS).

    Janssens AI, Ruytings M, Al-Chalabi A, Chio A, Hardiman O, Mcdermott CJ, Meyer T, Mora G, Van Damme P, Van Den Berg LH, Vanhaecht K, Winkler AS, Sermeus W; ALS-CARE Consortium.
    Amyotroph Lateral Scler Frontotemporal Degener. 2016 Jul-Aug;17(5-6):325-36. doi: 10.3109/21678421.2016.1167911. Epub 2016 Apr 14.
    PMID: 2707804

    Amyotroph Lateral Scler Frontotemporal Degener , Juli 2016

    Alterations int the hypothalamic melanocortin pathway in amyotrophic lateral sclerosis.

    Vercruysse P, Sinniger J, El Oussini H, Scekic-Zahirovic J, Dieterlé S, Dengler R, Meyer T, Zierz S, Kassubek J, Fischer W, Dreyhaupt J, Grehl T, Hermann A, Grosskreutz J, Witting A, Van Den Bosch L, Spreux-Varoquaux O; GERP ALS Study Group, Ludolph AC, Dupuis L.
    Brain. 2016 Apr;139(Pt 4):1106-22. doi: 10.1093/brain/aww004. Epub 2016 Mar 16.
    PMID: 26984187

    Brain, April 2016

    Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia.

    Freischmidt A, Wieland T, Richter B, Ruf W, Schaeffer V, Müller K, Marroquin N, Nordin F, Hübers A, Weydt P, Pinto S, Press R, Millecamps S, Molko N, Bernard E, Desnuelle C, Soriani MH, Dorst J, Graf E, Nordström U, Feiler MS, Putz S, Boeckers TM, Meyer T, Winkler AS, Winkelman J, de Carvalho M, Thal DR, Otto M, Brännström T, Volk AE, Kursula P, Danzer KM, Lichtner P, Dikic I, Meitinger T, Ludolph AC, Strom TM, Andersen PM, Weishaupt JH.
    Nat Neurosci. 2015 May;18(5):631-6. doi: 10.1038/nn.4000. Epub 2015 Mar 24.
    PMID: 25803835

    Nature Neuroscience, Mai 2015

    Percutaneous endoscopic gastrostomy in amyotrophic lateral sclerosis: a prospective observational study.

    Dorst J, Dupuis L, Petri S, Kollewe K, Abdulla S, Wolf J, Weber M, Czell D, Burkhardt C, Hanisch F, Vielhaber S, Meyer T, Frisch G, Kettemann D, Grehl T, Schrank B, Ludolph AC.
    J Neurol. 2015;262(4):849-58. doi: 10.1007/s00415-015-7646-2. Epub 2015 Jan 25.
    PMID: 25618254

    Journal of Neurology, Januar 2015

    A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicity.

    Joyce PI, Mcgoldrick P, Saccon RA, Weber W, Fratta P, West SJ, Zhu N, Carter S, Phatak V, Stewart M, Simon M, Kumar S, Heise I, Bros-Facer V, Dick J, Corrochano S, Stanford MJ, Luong TV, Nolan PM, Meyer T, Brandner S, Bennett DL, Ozdinler PH, Greensmith L, Fisher EM, Acevedo-Arozena A.
    Hum Mol Genet. 2015 Apr 1;24(7):1883-97. doi: 10.1093/hmg/ddu605. Epub 2014 Dec 2.
    PMID: 25468678

    Human Molecular Genetic, Dezember 2014

    Crowdsourced analysis of clinical trial data to predict amyotrophic lateral sclerosis progression.

    Küffner R, Zach N, Norel R, Hawe J, Schoenfeld D, Wang L, Li G, Fang L, Mackey L, Hardiman O, Cudkowicz M, Sherman A, Ertaylan G, Grosse-Wentrup M, Hothorn T, van Ligtenberg J, Macke JH, Meyer T, Schölkopf B, Tran L, Vaughan R, Stolovitzky G, Leitner ML.
    Nat Biotechnol. 2015 Jan;33(1):51-7. doi: 10.1038/nbt.3051. Epub 2014 Nov 2.
    PMID: 25362243

    nature biotechnology, November 2014

    Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: a multicenter survival study.

    van Doormaal PT, Ticozzi N, Gellera C, Ratti A, Taroni F, Chiò A, Calvo A, Mora G, Restagno G, Traynor BJ, Birve A, Lemmens R, van Es MA, Saris CG, Blauw HM, van Vught PW, Groen EJ, Corrado L, Mazzini L, Del Bo R, Corti S, Waibel S, Meyer T, Ludolph AC, Goris A, van Damme P, Robberecht W, Shatunov A, Fogh I, Andersen PM, D’Alfonso S, Hardiman O, Cronin S, Rujescu D, Al-Chalabi A, Landers JE, Silani V, van den Berg LH, Veldink JH.
    Neurobiol Aging. 2014 Oct;35(10):2420.e13-4. doi: 10.1016/j.neurobiolaging.2014.04.014. Epub 2014 Apr 19.
    PMID: 24838185

    Neurobiology of Aging, Oktober 2014

    Safety, pharmacokinetic, and functional effects of the nogo-a monoclonal antibody in amyotrophic lateral sclerosis: a randomized. first-in-human clinical trial.

    Meininger V, Pradat PF, Corse A, Al-Sarraj S, Rix Brooks B, Caress JB, Cudkowicz M, Kolb SJ, Lange D, Leigh PN, Meyer T, Milleri S, Morrison KE, Orrell RW, Peters G, Rothstein JD, Shefner J, Lavrov A, Williams N, Overend P, Price J, Bates S, Bullman J, Krull D, Berges A, Abila B, Meno-Tetang G, Wurthner J.
    PLoS One. 2014 May 19;9(5):e97803. doi: 10.1371/journal.pone.0097803. eCollection 2014.
    PMID: 24841795

    Plos One, Mai 2014

    A phase II-III trial of olesoxime in subjects with amyotrophic lateral sclerosis.

    Lenglet T, Lacomblez L, Abitbol JL, Ludolph A, Mora JS, Robberecht W, Shaw PJ, Pruss RM, Cuvier V, Meininger V; Mitotarget study group.
    Eur J Neurol. 2014 Mar;21(3):529-36. doi: 10.1111/ene.12344. Epub 2014 Jan 21.
    PMID: 24447620

    european journal of neurology, März 2014

    Live and let die: existential decision processes in a fatal disease.

    Lulé D, Nonnenmacher S, Sorg S, Heimrath J, Hautzinger M, Meyer T, Kübler A, Birbaumer N, Ludolph AC.
    J Neurol. 2014 Mar;261(3):518-25. doi: 10.1007/s00415-013-7229-z. Epub 2014 Jan 12.
    PMID: 24413639

    Journal of Neurology, März 2014

    Diffusion tensor imaging in amyotrophic lateral sclerosis – increased sensitivity with optimized region-of-interest delineation.

    Prokscha T, Guo J, Hirsch S, Braun J, Sack I, Meyer T, Scheel M.Clin Neuroradiol.
    2014 Mar;24(1):37-42. doi: 10.1007/s00062-013-0221-2. Epub 2013 May 14.
    PMID: 23670494

    Clinical Neuroradiology, März 2014

    In vivo waveguide elastography: effects of neurodegeneration in patients with amyotrophic lateral sclerosis.

    Romano A, Guo J, Prokscha T, Meyer T, Hirsch S, Braun J, Sack I, Scheel M.
    Magn Reson Med.2014 Dec;72(6):1755-61. doi: 10.1002/mrm.25067. Epub 2013 Dec 17.
    PMID: 24347290

    Magnetic Resonance in Medicine , Dezember 2013

    PGC-1α is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis.

    Eschbach J, Schwalenstöcker B, Soyal SM, Bayer H, Wiesner D, Akimoto C, Nilsson AC, Birve A, Meyer T, Dupuis L, Danzer KM, Andersen PM, Witting A, Ludolph AC, Patsch W, Weydt P.
    Hum Mol Genet. 2013 Sep 1;22(17):3477-84. doi: 10.1093/hmg/ddt202. Epub 2013 May 12.
    PMID: 23669350

    Human Molecular Genetics , September 2013

    Optical coherence tomography does not support optic nerve involvement in amyotrophic lateral sclerosis.

    Roth NM, Saidha S, Zimmermann H, Brandt AU, Oberwahrenbrock T, Maragakis NJ, Tumani H, Ludolph AC, Meyer T, Calabresi PA, Paul F.
    Eur J Neurol. 2013 Aug;20(8):1170-6. doi: 10.1111/ene.12146. Epub 2013 Apr 14.
    PMID: 23582075

    European Journal of Neurology , August 2013

    The dynactin p150 subunit: cell biology studies of sequence changes found in ALS/MND and Parkinsonian syndromes.

    Stockmann M, Meyer-Ohlendorf M, Achberger K, Putz S, Demestre M, Yin H, Hendrich C, Linta L, Heinrich J, Brunner C, Proepper C, Kuh GF, Baumann B, Langer T, Schwalenstöcker B, Braunstein KE, von Arnim C, Schneuwly S, Meyer T, Wong PC, Boeckers TM, Ludolph AC, Liebau S.J Neural Transm (Vienna).
    2013 May;120(5):785-98. doi: 10.1007/s00702-012-0910-z. Epub 2012 Nov 11.
    PMID: 23143281

    Journal of Neural Transmission, Mai 2013

    A novel optineurin truncating mutation and three glaucoma-associated missense variants in patients with familial amyotrophic lateral sclerosis in Germany.

    Weishaupt JH, Waibel S, Birve A, Volk AE, Mayer B, Meyer T, Ludolph AC, Andersen PM.
    Neurobiol Aging. 2013 May;34(5):1516.e9-15. doi: 10.1016/j.neurobiolaging.2012.09.007. Epub 2012 Oct 10.
    PMID: 23062601

    Neurobiology of Aging , Mai 2013

    Truncating mutations in FUS/TLS give rise to a more aggressive ALS-phenotype than missense mutations: a clinico-genetic study in Germany.

    Waibel S, Neumann M, Rosenbohm A, Birve A, Volk AE, Weishaupt JH, Meyer T, Müller U, Andersen PM, Ludolph AC.
    Eur J Neurol. 2013 Mar;20(3):540-6. doi: 10.1111/ene.12031. Epub 2012 Dec 6.
    PMID: 23217123

    European Journal of Neurology , März 2013

    A randomized, double blind, placebo-controlled trial of pioglitazone in combination with riluzole in amyotrophic lateral sclerosis.

    Dupuis L, Dengler R, Heneka MT, Meyer T, Zierz S, Kassubek J, Fischer W, Steiner F, Lindauer E, Otto M, Dreyhaupt J, Grehl T, Hermann A, Winkler AS, Bogdahn U, Benecke R, Schrank B, Wessig C, Grosskreutz J, Ludolph AC; GERP ALS Study Group.
    PLoS One. 2012;7(6):e37885. doi: 10.1371/journal.pone.0037885. Epub 2012 Jun 8.
    PMID: 22715372

    PLOS ONE , Juni 2012

    NIPA1 polyalanine repeat expansions are associated with amyotrophic lateral sclerosis.

    Blauw HM, van Rheenen W, Koppers M, Van Damme P, Waibel S, Lemmens R, van Vught PW, Meyer T, Schulte C, Gasser T, Cuppen E, Pasterkamp RJ, Robberecht W, Ludolph AC, Veldink JH, van den Berg LH.
    Hum Mol Genet. 2012 Jun 1;21(11):2497-502. doi: 10.1093/hmg/dds064. Epub 2012 Feb 28.
    PMID: 22378146

    Human Molecular Genetics , Juni 2012

    Ataxin-2 intermediate-length polyglutamine expansions in European ALS patients.

    Lee T, Li YR, Ingre C, Weber M, Grehl T, Gredal O, de Carvalho M, Meyer T, Tysnes OB, Auburger G, Gispert S, Bonini NM, Andersen PM, Gitler AD.
    Hum Mol Genet. 2011 May 1;20(9):1697-700. doi: 10.1093/hmg/ddr045. Epub 2011 Feb 3.
    PMID: 21292779

    Human Molecular Genetics, Mai 2011

    A large genome scan for rare CNVs in amyotrophic lateral sclerosis.

    Blauw HM, Al-Chalabi A, Andersen PM, van Vught PW, Diekstra FP, van Es MA, Saris CG, Groen EJ, van Rheenen W, Koppers M, Van’t Slot R, Strengman E, Estrada K, Rivadeneira F, Hofman A, Uitterlinden AG, Kiemeney LA, Vermeulen SH, Birve A, Waibel S, Meyer T, Cronin S, McLaughlin RL, Hardiman O, Sapp PC, Tobin MD, Wain LV, Tomik B, Slowik A, Lemmens R, Rujescu D, Schulte C, Gasser T, Brown RH Jr, Landers JE, Robberecht W, Ludolph AC, Ophoff RA, Veldink JH, van den Berg LH.
    Hum Mol Genet. 2010 Oct 15;19(20):4091-9. doi: 10.1093/hmg/ddq323. Epub 2010 Aug 4.
    PMID: 20685689

    Human Molecular Genetics, Oktober 2010

    Novel missense and truncating mutations in FUS/TLS in familial ALS.

    Waibel S, Neumann M, Rabe M, Meyer T, Ludolph AC.
    Neurology. 2010 Aug 31;75(9):815-7. doi: 10.1212/WNL.0b013e3181f07e26. Epub 2010 Jul 21.
    PMID: 20660363

    Neurology, July 2010

    Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.

    van Es MA, Veldink JH, Saris CG, Blauw HM, van Vught PW, Birve A, Lemmens R, Schelhaas HJ, Groen EJ, Huisman MH, van der Kooi AJ, de Visser M, Dahlberg C, Estrada K, Rivadeneira F, Hofman A, Zwarts MJ, van Doormaal PT, Rujescu D, Strengman E, Giegling I, Muglia P, Tomik B, Slowik A, Uitterlinden AG, Hendrich C, Waibel S, Meyer T, Ludolph AC, Glass JD, Purcell S, Cichon S, Nöthen MM, Wichmann HE, Schreiber S, Vermeulen SH, Kiemeney LA, Wokke JH, Cronin S, McLaughlin RL, Hardiman O, Fumoto K, Pasterkamp RJ, Meininger V, Melki J, Leigh PN, Shaw CE, Landers JE, Al-Chalabi A, Brown RH Jr, Robberecht W, Andersen PM, Ophoff RA, van den Berg LH.
    Nat Genet. 2009 Oct;41(10):1083-7. doi: 10.1038/ng.442. Epub 2009 Sep 6.PMID.
    PMID: 19734901

    nature genetics, September 2009

    No evidence of association of FLJ10986 and ITPR2 with ALS in a large German cohort.

    Fernández-Santiago R, Sharma M, Berg D, Illig T, Anneser J, Meyer T, Ludolph A, Gasser T.
    Neurobiol Aging. 2011 Mar;32(3):551.e1-4. doi: 10.1016/j.neurobiolaging.2009.04.018. Epub 2009 May 22.
    PMID: 19464757

    Neurobiology of Aging, Mai 2009

    Identification of novel Angiogenin (ANG) gene missense variants in German patients with amyotrophic lateral sclerosis.

    Fernández-Santiago R, Hoenig S, Lichtner P, Sperfeld AD, Sharma M, Berg D, Weichenrieder O, Illig T, Eger K, Meyer T, Anneser J, Münch C, Zierz S, Gasser T, Ludolph A.
    J Neurol. 2009 Aug;256(8):1337-42. doi: 10.1007/s00415-009-5124-4. Epub 2009 Apr 12.
    PMID: 19363631

    Journal of Neurology, August 2009

    Validity of the ALS-Depression-Inventory (ADI-12) – a new screening instrument for depressive disorders in patients with amyotrophic lateral sclerosis.

    Hammer EM, Häcker S, Hautzinger M, Meyer T, Kübler A.
    J Affect Disord. 2008 Jul;109(1-2):213-9. doi: 10.1016/j.jad.2007.11.012. Epub 2008 Feb 11.
    PMID: 18262283

    Journal of Affective Disorders, August 2008

    Guidelines for the preclinical in vivo evaluation of pharmacological active drugs for ALS/MND: report on the 142nd ENMC international workshop.

    Ludolph AC, Bendotti C, Blaugrund E, Hengerer B, Löffler JP, Martin J, Meininger V, Meyer T, Moussaoui S, Robberecht W, Scott S, Silani V, Van Den Berg LH; ENMC Group for the Establishment of Guidelines for the Conduct of Preclinical and Proof of Concept Studies in ALS/MND Models.
    Amyotroph Lateral Scler. 2007 Aug;8(4):217-23. doi: 10.1080/17482960701292837.
    PMID: 17653919

    Journal Amyotrophic Lateral Sclerosis, August 2007

    Familial ALS in Germany: origin of the R115G SOD1 mutation by a founder effect.

    Niemann S, Joos H, Meyer T, Vielhaber S, Reuner U, Gleichmann M, Dengler R, Müller U.
    J Neurol Neurosurg Psychiatry. 2004 Aug;75(8):1186-8. doi: 10.1136/jnnp.2003.028324.
    PMID: 15258228

    Journal of Neurology, Neurosurgery & Psychiatry, August 2004

    The role of excitotoxicity in ALS – what is the evidence?

    Ludolph AC, Meyer T, Riepe MW.
    J Neurol. 2000 Mar;247 Suppl 1:I7-16. doi: 10.1007/s004150050552.
    PMID: 10795882

    Journal of Neurology, März 2000

    Antiglutamate therapy of ALS – which is the next step?

    Ludolph AC, Meyer T, Riepe MW.
    J Neural Transm Suppl. 1999;55:79-95. doi: 10.1007/978-3-7091-6369-6_8.
    PMID: 10335495

    Advances in Research on Neurodegeneration pp 79-95, 1999

    Molecular biology findings in amyotrophic lateral sclerosis.

    Bachus R, Claus A, Meyer T, Riepe M, Ludolph AC.
    Nervenarzt. 1997 Oct;68(10):785-91. doi: 10.1007/s001150050195.
    PMID: 9441250

    Nervenarzt, Oktober 1997